个人简介
主要从事以多肽为识别元件的亲和色谱分离分析基础与应用研究。围绕蛋白质靶向分子探针、高性能分离材料、以及生物膜界面精准化学测量等方面开展研究工作，为生理病理过程蛋白靶标的检测、功能解析和化学干预提供新工具和新方法。以通讯或第一作者在Angew. Chem. Int. Ed., Adv. Healthcare Mater., Chem. Sci., Anal. Chem.等期刊发表学术论文40余篇。授权中国发明专利8项。曾获中国分析测试协会科学技术奖（排名第二）。入选2015年度中国科学院青年创新促进会会员。2021年获国家自然科学基金委优秀青年基金项目资助。任中国化学会色谱专业委员会委员、北京色谱学会常务理事。
研究领域和方向
1. 亲和多肽的设计与定向筛选
2. 基于多肽界面工程化的高性能分离材料
3. 靶向分子开关和活体化学测量与干预
4. 蛋白团簇/生物颗粒高选择性分离分析
教育背景
2004.9-2009.7 中国科学院化学研究所，分析化学，理学博士
2000.9-2004.6 武汉大学，化学，理学学士
工作履历
2025.10-至今 麻豆传媒
，教授
2017.2-2018.6 美国Texas A&M University, 访问学者
2009.7-2025.10 中国科学院化学研究所，助理研究员，副研究员，研究员
研究成果
1.Kun Xu, Han Gao, Yongming Li, Yulong Jin, Rui Zhao*, Yanyan Huang*. Synthetic peptides with genetic-codon-tailored affinity for assembling tetraspanin CD81 at cell interfaces and inhibiting cancer metastasis. Angew. Chem. Int. Ed., 2024, 63, e202400129.
2.Yanyan Huang, Chi Zhan, Yang Yang, Lingna Wang, Huifei Zhong, Yang Yu, Xi-Sha Zhang, Cheng Li, Yulong Jin, Guanxin Zhang, Rui Zhao*, Deqing Zhang*. Tuning proapoptotic activity of a phosphoric-acid-tethered tetraphenylethene by visible-light- triggered isomerization and switchable protein interactions for cancer therapy. Angew. Chem. Int. Ed., 2022, 61, e2022083.
3.Yanyan Huang, Xue You, Lingna Wang, Guanxin Zhang, Shilang Gui, Yulong Jin, Rui Zhao*, Deqing Zhang*. Pyridinium-substituted tetraphenylethylenes functionalized with alkyl chains as autophagy modulators for cancer therapy. Angew. Chem. Int. Ed., 2020, 59, 10042-10051.
4.Xiongwei Tang, Huixia Feng, Yongming Li, Tingting Miao*, Han Gao, Rui Zhao, Yanyan Huang*. Bioinspired peptide sensors with tailorable structure for specific and in-situ tracking of Hg2+ biodistribution in living cells upon acute exposure. Biosens. Bioelectron., 2025, 269, 116940.
5.Han Gao, Zhirong He, Jian Chen, Huixia Feng, Rui Zhao, Yanyan Huang*. Macrocyclic peptide-based dual-sensor platform for linkage-specific visualization of ubiquitin chain assembling in live cells. Anal. Chem., 2025, 97, 2351-2358.
6.Kun Xu, Yanting Hao, Han Gao, Huixia Feng, Jian Chen, Rui Zhao, Yanyan Huang*. Engineering peptide-based molecular baits for targeted fishing and protein profiling of exosomes as a liquid biopsy for gastrointestinal adenocarcinoma. Anal. Chem., 2025, 97, 741-748.
7.Jian Chen, Huixia Feng, Chi Zhan, Han Gao, Rui Zhao, Deqing Zhang, Guanxin Zhang*, Yanyan Huang*. Bioinspired chemosensor with configuration-dependent affinity for localized tracking of labile Zn2+ during neuronal differentiation. Anal. Chem., 2025, 97, 10782–10791.
8.Yuanyuan Zhu, Yanyan Huang*, Tian-Hao Yan, Jialuo Li, Yongming Li, Hannah F. Drake, Huifei Zhong, Yulong Jin, Rui Zhao, Hong-Cai Zhou*. Metal-organic framework-based nanoheater with photo-triggered cascade effects for on-demand suppression of cellular thermoresistance and synergistic cancer therapy. Adv. Healthcare Mater., 2022, 11, 2200004.
9.Yongming Li, Huifei Zhong, Yulong Jin, Bo Guan, Jiling Yue, Rui Zhao, Yanyan Huang*. Metal–organic framework accelerated one-step capture and reduction of palladium to catalytically active nanoparticles. ACS Appl. Mater. Interfaces, 2022, 14, 40408−40417.
10.Huifei Zhong, Chunwang Yuan, Jiayuan He, Yang Yu, Yulong Jin, Yanyan Huang*, Rui Zhao. Engineering peptide-functionalized biomimetic nanointerfaces for synergetic capture of circulating tumor cells in an EpCAM-independent manner. Anal. Chem., 2021, 93, 9778-9787.